冷应激对大鼠肝脏中细胞色素P450 1（CYP1）调控的芳烃受体（AhR）依赖性途径相关基因表达的影响。
Effect of cold stress on expression of genes for the AhR-dependent pathway of CYP1 regulation in rat liver.
作者信息
Perepechaeva M L, Sidorova Yu A, Grishanova A Yu
机构信息
Laboratory for Biochemistry of Foreign Compounds, Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
出版信息
Bull Exp Biol Med. 2006 Mar;141(3):315-8. doi: 10.1007/s10517-006-0159-3.
The level of mRNA for cytochromes P450 (CYP1A1, CYP1A2, and CYP1B1) and CYP1 regulatory proteins (heat shock protein, aryl hydrocarbon receptor, aryl hydrocarbon receptor repressor, and aryl hydrocarbon receptor nuclear translocator) was measured in the liver of rats after cold stress (4 degrees C). The CYP1A1 mRNA level increased and remained high for 10 days after 5-day cold exposure. The level of mRNA for CYP1A2, heat shock protein, and aryl hydrocarbon receptor nuclear translocator decreased by the 10th day. The level of mRNA for CYP1B1, aryl hydrocarbon receptor, and aryl hydrocarbon receptor nuclear translocator remained unchanged over this period.
在冷应激（4摄氏度）后，测定了大鼠肝脏中细胞色素P450（CYP1A1、CYP1A2和CYP1B1）及CYP1调节蛋白（热休克蛋白、芳烃受体、芳烃受体阻遏蛋白和芳烃受体核转运蛋白）的mRNA水平。5天冷暴露后，CYP1A1 mRNA水平升高，并在10天内保持高位。到第10天时，CYP1A2、热休克蛋白和芳烃受体核转运蛋白的mRNA水平下降。在此期间，CYP1B1、芳烃受体和芳烃受体核转运蛋白的mRNA水平保持不变。
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