Johannessen Erik A, Wang Lei, Wyse Cathy, Cumming David R S, Cooper Jon M
Lifecare AS, P.O. Box 1077, 3194 Horten, Norway.
IEEE Trans Biomed Eng. 2006 Nov;53(11):2333-40. doi: 10.1109/TBME.2006.883698.
In this paper, we present a radiotelemetry sensor, designed as a lab-in-a-pill, which incorporates a two-channel microfabricated sensor platform for real-time measurements of temperature and pH. These two parameters have potential application for use in remote biological sensing (for example they may be used as markers that reflect the physiological environment or as indicators for disease, within the gastrointestinal tract). We have investigated the effects of biofouling on these sensors, by exploring their response time and sensitivity in a model in vitro gastrointestinal system. The artificial gastric and intestinal solutions used represent a model both for fasting, as well as for the ingestion of food and subsequent digestion to gastrointestinal chyme. The results showed a decrease in pH sensitivity after exposure of the sensors for 3 h. The response time also increased from an initial measurement time of 10 s in pure GI juice, to ca. 25 s following the ingestion of food and 80 s in simulated chyme. These in vitro results indicate that changes in viscosity in our model gastrointestinal system had a pronounced effect on the unmodified sensor.
在本文中，我们展示了一种设计为“药中实验室”的无线电遥测传感器，它集成了一个双通道微制造传感器平台，用于实时测量温度和pH值。这两个参数在远程生物传感方面具有潜在应用（例如，它们可作为反映生理环境的标志物或胃肠道内疾病的指标）。我们通过在体外胃肠道系统模型中探究其响应时间和灵敏度，研究了生物污垢对这些传感器的影响。所使用的人工胃液和肠液既代表禁食状态的模型，也代表摄入食物并随后消化成胃肠食糜的模型。结果显示，传感器暴露3小时后pH灵敏度降低。响应时间也从在纯胃肠液中最初测量的10秒增加到摄入食物后的约25秒以及在模拟食糜中的80秒。这些体外实验结果表明，我们模型胃肠道系统中粘度的变化对未改性的传感器有显著影响。
