Kobayashi Yoshiro
Division of Molecular Medicine, Department of Biomolecular Science, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan.
Crit Rev Immunol. 2006;26(4):307-16. doi: 10.1615/critrevimmunol.v26.i4.20.
Neutrophil infiltration is mainly mediated by ELR+ CXC chemokines and is regulated through interactions between various stimulants and cells, which are perhaps more complex than previously thought. In this review, I describe the current view of the roles of neutrophil-selective chemokines such as IL-8, MIP-2, and KC by choosing several in vivo models. I also illustrate how these three chemokines are induced and how they are involved in neutrophil infiltration. Finally, I introduce synthetic compounds with high efficacy in the prevention of ischemia reperfusion injury.
中性粒细胞浸润主要由ELR + CXC趋化因子介导，并通过各种刺激物与细胞之间的相互作用进行调节，其复杂性可能超出以往的认知。在这篇综述中，我通过选取几种体内模型来阐述目前对诸如白细胞介素-8、巨噬细胞炎性蛋白-2和KC等中性粒细胞选择性趋化因子作用的观点。我还说明了这三种趋化因子是如何被诱导以及它们如何参与中性粒细胞浸润。最后，我介绍了在预防缺血再灌注损伤方面具有高效能的合成化合物。
