Liang Bojian, Fujibayashi Shunsuke, Fujita Hiroshi, Ise Kentaro, Neo Masashi, Nakamura Takashi
Department of Orthopaedic Surgery, Kyoto University, Japan.
J Long Term Eff Med Implants. 2006;16(4):291-9. doi: 10.1615/jlongtermeffmedimplants.v16.i4.30.
We report a long-term study of bioactive bone cement (BABC) in a canine total hip arthroplasty (THA) at follow-up of 8 years. Previous studies have shown excellent biomechanical and histological results at follow-up of 6, 12, and 24 months. In the present study, THA was performed in a beagle dog using BABC consisting of an apatite- and wollastonite-containing glass ceramic (AW-GC) powder and SiO2 powder as the filler and a bisphenol-a-glycidyl methacrylate (Bis-GMA) based resin as the organic matrix. Histological examination showed direct bonding between BABC and bone without any intervening soft tissue layer at the BABC-bone interface. A reactive layer, through which BABC bonded to the bone, was observed thicker at 8 years than it was at 24 weeks. No adverse effects of BABC were observed. BABC maintained the high bioactivity and direct bonding to bone in a canine THA at follow-up of 8 years.
我们报告了一项在犬类全髋关节置换术（THA）中对生物活性骨水泥（BABC）进行的长达8年的随访研究。先前的研究表明，在6个月、12个月和24个月的随访中，其生物力学和组织学结果优异。在本研究中，在一只比格犬身上进行了THA，使用的BABC由含有磷灰石和硅灰石的玻璃陶瓷（AW-GC）粉末和SiO₂粉末作为填充剂，以及基于双酚A-甲基丙烯酸缩水甘油酯（Bis-GMA）的树脂作为有机基质组成。组织学检查显示，BABC与骨之间直接结合，在BABC-骨界面处没有任何中间软组织层。观察到一个反应层，通过该反应层BABC与骨结合，在8年时比在24周时更厚。未观察到BABC的不良反应。在8年的随访中，BABC在犬类THA中保持了高生物活性和与骨的直接结合。
