犬全髋关节置换术中生物活性骨水泥的长期随访研究
Long-term follow-up study of bioactive bone cement in canine total hip arthroplasty.
作者信息
Liang Bojian, Fujibayashi Shunsuke, Fujita Hiroshi, Ise Kentaro, Neo Masashi, Nakamura Takashi
机构信息
Department of Orthopaedic Surgery, Kyoto University, Japan.
出版信息
J Long Term Eff Med Implants. 2006;16(4):291-9. doi: 10.1615/jlongtermeffmedimplants.v16.i4.30.
We report a long-term study of bioactive bone cement (BABC) in a canine total hip arthroplasty (THA) at follow-up of 8 years. Previous studies have shown excellent biomechanical and histological results at follow-up of 6, 12, and 24 months. In the present study, THA was performed in a beagle dog using BABC consisting of an apatite- and wollastonite-containing glass ceramic (AW-GC) powder and SiO2 powder as the filler and a bisphenol-a-glycidyl methacrylate (Bis-GMA) based resin as the organic matrix. Histological examination showed direct bonding between BABC and bone without any intervening soft tissue layer at the BABC-bone interface. A reactive layer, through which BABC bonded to the bone, was observed thicker at 8 years than it was at 24 weeks. No adverse effects of BABC were observed. BABC maintained the high bioactivity and direct bonding to bone in a canine THA at follow-up of 8 years.
我们报告了一项在犬类全髋关节置换术（THA）中对生物活性骨水泥（BABC）进行的长达8年的随访研究。先前的研究表明，在6个月、12个月和24个月的随访中，其生物力学和组织学结果优异。在本研究中，在一只比格犬身上进行了THA，使用的BABC由含有磷灰石和硅灰石的玻璃陶瓷（AW-GC）粉末和SiO₂粉末作为填充剂，以及基于双酚A-甲基丙烯酸缩水甘油酯（Bis-GMA）的树脂作为有机基质组成。组织学检查显示，BABC与骨之间直接结合，在BABC-骨界面处没有任何中间软组织层。观察到一个反应层，通过该反应层BABC与骨结合，在8年时比在24周时更厚。未观察到BABC的不良反应。在8年的随访中，BABC在犬类THA中保持了高生物活性和与骨的直接结合。
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