大麻素与过氧化物酶体增殖物激活受体α信号传导

Cannabinoids and PPARalpha signalling.

作者信息

Sun Y, Alexander S P H, Kendall D A, Bennett A J

机构信息

School of Biomedical Sciences, University of Nottingham, Nottingham NG7 2UH, UK.

出版信息

Biochem Soc Trans. 2006 Dec;34(Pt 6):1095-7. doi: 10.1042/BST0341095.

DOI:10.1042/BST0341095

PMID:17073758

Abstract

Cannabinoids have been shown to possess anti-inflammatory and neuroprotective properties, which were proposed to occur mainly via activation of the G-protein-coupled receptor CB(1) (cannabinoid receptor 1). Recently, certain cannabinoids have been reported to be ligands for members of the nuclear receptor transcription factor superfamily known as PPARs (peroxisome-proliferator-activated receptors). This review summarizes the evidence for cannabinoid activation of PPARs and identifies a new intracellular target for cannabinoids as therapeutic agents for neuroprotective treatment.

摘要

大麻素已被证明具有抗炎和神经保护特性，据推测这些特性主要通过激活G蛋白偶联受体CB(1)（大麻素受体1）而产生。最近，有报道称某些大麻素是核受体转录因子超家族成员PPARs（过氧化物酶体增殖物激活受体）的配体。这篇综述总结了大麻素激活PPARs的证据，并确定了大麻素作为神经保护治疗药物的一个新的细胞内靶点。