Variend S, Gerrard M, Norris P D, Goepel J R
Department of Pathology, Sheffield Children's Hospital, UK.
Histopathology. 1991 Jan;18(1):45-51. doi: 10.1111/j.1365-2559.1991.tb00813.x.
Two cases are reported of intra-abdominal small cell tumours expressing concomitant neural and epithelial differentiation. These features were discernible on conventional microscopy and supported immunocytochemically. Immunoreactive vimentin was also revealed in both tumours, and, in addition, one showed focal desmin positivity. Epithelial differentiation in both tumours was confirmed ultrastructurally. The tumours were interpreted to represent a variant of peripheral primitive neuroectodermal tumour, and the report serves to emphasize a potential among such tumours for complex differentiation. The neoplasms are compared with other similar tumours reported recently in children.
报告了两例腹腔内小细胞肿瘤，其同时表达神经和上皮分化。这些特征在传统显微镜下可辨别，并得到免疫细胞化学的支持。在这两种肿瘤中还发现了免疫反应性波形蛋白，此外，其中一例显示局灶性结蛋白阳性。通过超微结构证实了两种肿瘤中的上皮分化。这些肿瘤被解释为外周原始神经外胚层肿瘤的一种变体，该报告旨在强调此类肿瘤中存在复杂分化的可能性。将这些肿瘤与最近报道的儿童其他类似肿瘤进行了比较。
