儿童焦虑症中错误相关负波（ERN）增加：事件相关电位及源定位
Increased error-related negativity (ERN) in childhood anxiety disorders: ERP and source localization.
作者信息
Ladouceur Cecile D, Dahl Ronald E, Birmaher Boris, Axelson David A, Ryan Neal D
机构信息
Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, PA 15213, USA.
出版信息
J Child Psychol Psychiatry. 2006 Oct;47(10):1073-82. doi: 10.1111/j.1469-7610.2006.01654.x.
BACKGROUND
In this study we used event-related potentials (ERPs) and source localization analyses to track the time course of neural activity underlying response monitoring in children diagnosed with an anxiety disorder compared to age-matched low-risk normal controls.
METHODS
High-density ERPs were examined following errors on a flanker task from 12 children between 8 and 14 years old diagnosed with an anxiety disorder (ANX) and 13 age-matched low-risk normal controls (LRNC).
RESULTS
Children diagnosed with an anxiety disorder had increased error-related negativity (ERN) amplitude. The neural generators of the ERN in the ANX group were estimated to be localized in the anterior cingulate cortex (ACC). There were no significant group differences in P(E) amplitude.
CONCLUSIONS
These data provide evidence for increased ERN amplitude localized to the ACC in children diagnosed with an anxiety disorder, suggesting altered maturational patterns of the ACC circuitry early in the course of this illness.
背景
在本研究中，我们使用事件相关电位（ERP）和源定位分析，来追踪与年龄匹配的低风险正常对照组相比，被诊断为焦虑症的儿童在反应监测过程中神经活动的时间进程。
方法
对12名8至14岁被诊断为焦虑症（ANX）的儿童和13名年龄匹配的低风险正常对照组（LRNC）在侧翼任务中出现错误后进行高密度ERP检测。
结果
被诊断为焦虑症的儿童错误相关负波（ERN）幅度增加。焦虑症组ERN的神经发生器估计定位于前扣带回皮质（ACC）。P（E）幅度在两组间无显著差异。
结论
这些数据为被诊断为焦虑症的儿童中定位于ACC的ERN幅度增加提供了证据，表明在该疾病病程早期ACC回路的成熟模式发生了改变。
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