Yang Chun-Yuh, Hsieh Hui-Ju, Tsai Shang-Shyue, Wu Trong-Neng, Chiu Hui-Fen
Institute of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan.
J Toxicol Environ Health A. 2006 Nov;69(22):2033-40. doi: 10.1080/15287390600746181.
With growing evidence of the association between daily mortality and air pollution exposure in adults, it is important to investigate whether infants are also susceptible. The purpose of this study was to examine the relationship between air pollution exposure and postneonatal, defined as infant of more than 27 d and less than 1 yr old, mortality in Taipei, Taiwan's largest city, which has a subtropical climate, for the period 1994-2000, using a case-crossover analysis. This design is an alternative to Poisson time-series regression for studying the short-term adverse health effects of air pollution. The air pollutants examined included particulate matter (PM10), sulfur dioxide (SO2), ozone (O3), nitrogen dioxide (NO2), and carbon monoxide (CO). The risk of postneonatal deaths was estimated to increase by 3.1% for PM10, 4.1% for SO2, 1.7% for NO2, 3.8% for CO, and 0.1% for O3 for each interquartile range change, respectively. However, the associations were without statistical significance. The established link between air pollution levels and infant mortality may not be as strong in cities with subtropical climates, although other factors such as differences in pollutant component composition or the underlying health of the postneonates may explain the lack of a strong association in this study. Further studies of this type in cities with varying climates and cultures are needed.
随着越来越多证据表明成年人的每日死亡率与空气污染暴露之间存在关联,研究婴儿是否也易受影响就显得很重要。本研究的目的是利用病例交叉分析,考察1994年至2000年期间,在台湾最大城市台北(该城市属亚热带气候)空气污染暴露与出生后(定义为出生27天以上、1岁以下的婴儿)死亡率之间的关系。这种设计是研究空气污染短期不良健康影响的泊松时间序列回归的替代方法。所考察的空气污染物包括颗粒物(PM10)、二氧化硫(SO2)、臭氧(O3)、二氧化氮(NO2)和一氧化碳(CO)。每四分位数间距变化时,出生后死亡风险估计分别因PM10增加3.1%、因SO2增加4.1%、因NO2增加1.7%、因CO增加3.8%、因O3增加0.1%。然而,这些关联无统计学意义。在亚热带气候城市中,空气污染水平与婴儿死亡率之间已确立的联系可能没那么强,不过诸如污染物成分差异或出生后婴儿的潜在健康状况等其他因素,可能解释了本研究中缺乏强关联的原因。需要在气候和文化各异的城市开展此类进一步研究。