Butler Pamela D, Hoptman Matthew J, Nierenberg Jay, Foxe John J, Javitt Daniel C, Lim Kelvin O
Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd., Orangeburg NY, 10962, USA.
Am J Psychiatry. 2006 Nov;163(11):2011-3. doi: 10.1176/ajp.2006.163.11.2011.
Patients with schizophrenia have visual-processing deficits. This study examines visual white matter integrity as a potential mechanism for these deficits.
Diffusion tensor imaging was used to examine white matter integrity at four levels of the visual system in 17 patients with schizophrenia and 21 comparison subjects. The levels examined were the optic radiations, the striate cortex, the inferior parietal lobule, and the fusiform gyrus.
Schizophrenia patients showed a significant decrease in fractional anisotropy in the optic radiations but not in any other region.
This finding indicates that white matter integrity is more impaired at initial input, rather than at higher levels of the visual system, and supports the hypothesis that visual-processing deficits occur at the early stages of processing.
精神分裂症患者存在视觉处理缺陷。本研究将视觉白质完整性作为这些缺陷的一种潜在机制进行研究。
采用扩散张量成像技术,对17例精神分裂症患者和21名对照者视觉系统的四个水平的白质完整性进行检测。检测的水平包括视辐射、纹状皮质、顶下小叶和梭状回。
精神分裂症患者视辐射的各向异性分数显著降低,但其他区域未见明显降低。
这一发现表明,白质完整性在视觉系统的初始输入阶段受损更严重,而非在更高水平,支持了视觉处理缺陷发生在处理早期阶段的假说。