Nagai Hiroichi, Teramachi Hitomi, Tuchiya Teruo
Department of Clinical Pharmacology, Gifu Pharmaceutical University, Gifu, Japan.
Allergol Int. 2006 Mar;55(1):35-42. doi: 10.2332/allergolint.55.35.
Research over the past decade has provided information concerning the onset and treatment of allergic diseases, including bronchial asthma, allergic rhinitis and atopic dermatitis. Recent studies also indicated that allergic inflammation is the basic pathophysiology of allergic diseases and is closely associated with their progression and exacerbation. Our understanding of the mechanism of allergic inflammation with regard to therapeutic agents has improved as a result of immunological and molecular biological studies. While much effort has been paid to developing a new anti-allergic drug, allergic disease has yet to be completely conquered. More extensive research will allow the development of new therapeutics to combat allergic diseases. This article provides an overview of recent advances in the development of anti-allergic drugs.
过去十年的研究提供了有关过敏性疾病（包括支气管哮喘、过敏性鼻炎和特应性皮炎）的发病和治疗的信息。最近的研究还表明，过敏性炎症是过敏性疾病的基本病理生理学，并且与其进展和加重密切相关。由于免疫学和分子生物学研究，我们对治疗药物相关的过敏性炎症机制的理解有所提高。虽然在开发新的抗过敏药物方面已经付出了很多努力，但过敏性疾病尚未被完全攻克。更广泛的研究将有助于开发对抗过敏性疾病的新疗法。本文概述了抗过敏药物开发的最新进展。
