Hurd Yasmin L
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA.
CNS Spectr. 2006 Nov;11(11):855-62. doi: 10.1017/s1092852900015005.
There is a significant heritability of drug addiction disorders, but potential genes that may underlie such vulnerability have not been clearly identified. Common neurobiological candidates for drug abuse include genes related to dopamine, opioid neuropeptide, and glutamate transmission that play important roles in drug reward and inhibitory control. This article provides an overview of genetic polymorphisms linked to these neurobiological systems, particularly in relation to psychostimulant- and opioid-addiction vulnerability.
药物成瘾性疾病存在显著的遗传易感性，但可能构成这种易感性基础的潜在基因尚未明确鉴定出来。药物滥用常见的神经生物学候选基因包括与多巴胺、阿片类神经肽和谷氨酸传递相关的基因，这些基因在药物奖赏和抑制控制中发挥重要作用。本文概述了与这些神经生物学系统相关的基因多态性，特别是与精神兴奋剂和阿片类药物成瘾易感性的关系。
