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P物质对原位冠状动脉内皮细胞膜电位的影响。

Effect of substance P on the membrane potential of coronary arterial endothelial cells in situ.

作者信息

Bény J L

机构信息

Département de Zoologie et Biologie Animale, Université de Genéve, Switzerland.

出版信息

Agents Actions. 1990 Nov;31(3-4):317-20. doi: 10.1007/BF01997626.

DOI:10.1007/BF01997626
PMID:1707586
Abstract

The membrane potential of the endothelial cells on a strip of pig coronary artery was recorded. The fluorescent dye lucifer yellow was injected into the recorded cell in order to prove its identity. We show that substance P transiently hyperpolarized these cells. The function of the endothelial cell hyperpolarization could be important for the role played by the endothelium and the kinins in inflammation.

摘要

记录了猪冠状动脉条带上内皮细胞的膜电位。将荧光染料路西法黄注入记录的细胞以证明其身份。我们发现P物质可使这些细胞短暂超极化。内皮细胞超极化的功能对于内皮和激肽在炎症中的作用可能很重要。

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本文引用的文献

1
Polyethylene glycol embedding: a technique compatible with immunocytochemistry, enzyme histochemistry, histofluorescence and intracellular staining.聚乙二醇包埋：一种与免疫细胞化学、酶组织化学、组织荧光法及细胞内染色兼容的技术。
J Neurosci Methods. 1983 Jan;7(1):27-41. doi: 10.1016/0165-0270(83)90016-x.
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Effects of neurokinins on the isolated pig coronary artery.
Eur J Pharmacol. 1987 Jun 4;137(2-3):149-54. doi: 10.1016/0014-2999(87)90215-9.
3
Hyperpolarization and increased free calcium in acetylcholine-stimulated endothelial cells.乙酰胆碱刺激的内皮细胞中的超极化和游离钙增加。
Am J Physiol. 1988 Oct;255(4 Pt 2):H965-9. doi: 10.1152/ajpheart.1988.255.4.H965.
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Histamine-induced inward currents in cultured endothelial cells from human umbilical vein.组胺诱导人脐静脉培养内皮细胞产生的内向电流。
Br J Pharmacol. 1988 Oct;95(2):429-36. doi: 10.1111/j.1476-5381.1988.tb11663.x.
5
Propagation of vasomotor responses coordinates arteriolar resistances.血管舒缩反应的传播协调小动脉阻力。
Am J Physiol. 1989 Mar;256(3 Pt 2):H832-7. doi: 10.1152/ajpheart.1989.256.3.H832.
6
Effect of membrane potential on cytosolic calcium of bovine aortic endothelial cells.膜电位对牛主动脉内皮细胞胞质钙的影响。
Am J Physiol. 1989 Sep;257(3 Pt 2):H778-84. doi: 10.1152/ajpheart.1989.257.3.H778.
7
Dye and electrical coupling of endothelial cells in situ.内皮细胞在体的染料偶联与电偶联
Tissue Cell. 1989;21(6):797-802. doi: 10.1016/0040-8166(89)90030-x.
8
Substance P and bradykinin hyperpolarize pig coronary artery endothelial cells in primary culture.P物质和缓激肽可使原代培养的猪冠状动脉内皮细胞超极化。
Blood Vessels. 1989;26(4):228-34. doi: 10.1159/000158770.
9
The 1988 Ulf Euler Lecture. Substancce P: from extract to excitement.1988年乌尔夫·欧拉讲座。P物质：从提取物到兴奋物质。
Acta Physiol Scand. 1988 Aug;133(4):435-54. doi: 10.1111/j.1748-1716.1988.tb08427.x.
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Ultrastructural localisation of serotonin and substance P in vascular endothelial cells of rat femoral and mesenteric arteries.大鼠股动脉和肠系膜动脉血管内皮细胞中5-羟色胺和P物质的超微结构定位
Anat Embryol (Berl). 1988;178(2):137-42. doi: 10.1007/BF02463647.