Anderson Richard B, Newgreen Donald F, Young Heather M
Department of Anatomy and Cell Biology, University of Melbourne, 3010, VIC, Australia.
Adv Exp Med Biol. 2006;589:181-96. doi: 10.1007/978-0-387-46954-6_11.
The formation of the enteric nervous system (ENS) is a particularly interesting example of the migratory ability of the neural crest and of the complexity of structures to which neural crest cells contribute. The distance that neural crest cells migrate to colonize the entire length of the gastrointestinal tract exceeds that of any other neural crest cell population. Furthermore, this migration takes a long time--over 25% of the gestation period for mice and around 3 weeks in humans. After colonizing the gut, neural crest-derived cells within the gut wall then differentiate into glial cells plus many different types of neurons, and generate the most complex part of the peripheral nervous system.
肠神经系统（ENS）的形成是神经嵴迁移能力以及神经嵴细胞所贡献的结构复杂性的一个特别有趣的例子。神经嵴细胞迁移以定植整个胃肠道长度的距离超过了任何其他神经嵴细胞群体。此外，这种迁移需要很长时间——小鼠妊娠期的25%以上，人类约3周。在定植肠道后，肠壁内源自神经嵴的细胞随后分化为神经胶质细胞以及许多不同类型的神经元，并产生外周神经系统最复杂的部分。
