Nederkoorn P J, Stam J
Academisch Medisch Centrum/Universiteit van Amsterdam, afd. Neurologie, Postbus 22.660, 1100, DD Amsterdam.
Ned Tijdschr Geneeskd. 2006 Oct 14;150(41):2259.
A recent trial revealed a reduction in ischaemic infarcts after carotid endarterectomy in patients with asymptomatic carotid stenosis. However, the number needed to treat (NNT) was 19 to prevent one stroke in 5 years, a modest effect in comparison to the trials with symptomatic patients (a NNT of only 6 in patients with a symptomatic stenosis of 70-99%). Furthermore, the number of surgical complications outweighs the benefits of surgery during the first two years after treatment. Finally, the benefits also included the prevention of contralateral strokes, whereas it is unlikely that these are prevented by endarterectomy. Therefore, endarterectomy should not be performed routinely in asymptomatic persons.
最近一项试验显示,无症状性颈动脉狭窄患者行颈动脉内膜切除术后缺血性梗死有所减少。然而,需要治疗的人数(NNT)为19,才能在5年内预防1次中风,与有症状患者的试验相比效果一般(有症状性狭窄70%-99%的患者NNT仅为6)。此外,治疗后前两年手术并发症的数量超过了手术的益处。最后,益处还包括预防对侧中风,而内膜切除术不太可能预防这些中风。因此,无症状者不应常规进行内膜切除术。