新一代抗抑郁药治疗的青少年抑郁症患者的自杀行为：荟萃分析

Suicidal behaviour in youths with depression treated with new-generation antidepressants: meta-analysis.

作者信息

Dubicka Bernadka, Hadley Sarah, Roberts Christopher

机构信息

University Department of Child and Adolescent Psychiatry, Royal Manchester Children's Hospital, Pendlebury, Manchester M27 4HA, UK.

出版信息

Br J Psychiatry. 2006 Nov;189:393-8. doi: 10.1192/bjp.bp.105.011833.

DOI:10.1192/bjp.bp.105.011833

PMID:17077427

Abstract

BACKGROUND

Concern exists that antidepressants can cause suicidality in youths with depression.

AIMS

To determine the pooled risk of self-harm and suicidal behaviour from randomised trials of newer antidepressants.

METHOD

A meta-analysis was carried out to calculate odds ratios for the combined data.

RESULTS

Self-harm or suicide-related events occurred in 71 of 1487 (4.8%) of depressed youths treated with antidepressants v. 38 of 1254 (3.0%) of those given placebo (fixed effects odds ratio 1.70, 95% CI 1.13-2.54, P=0.01). There was a trend for individual suicidal thoughts, attempts and self-harm to occur more often in youths taking antidepressants than in those given placebo, but none of these differences was statistically significant.

CONCLUSIONS

Antidepressants may cause a small short-term risk of self-harm or suicidal events in children and adolescents with major depressive disorder.

摘要

背景

人们担心抗抑郁药会导致患有抑郁症的青少年出现自杀倾向。

目的

确定新型抗抑郁药随机试验中自我伤害和自杀行为的合并风险。

方法

进行一项荟萃分析以计算合并数据的比值比。

结果

接受抗抑郁药治疗的1487名抑郁青少年中有71人（4.8%）发生了自我伤害或与自杀相关的事件，而接受安慰剂治疗的1254人中有38人（3.0%）发生了此类事件（固定效应比值比1.70，95%置信区间1.13 - 2.54，P = 0.01）。服用抗抑郁药的青少年出现个体自杀念头、自杀未遂和自我伤害的趋势比服用安慰剂的青少年更频繁，但这些差异均无统计学意义。