青少年期和青年期遗传及环境因素对抑郁症状影响的变化
Changes in genetic and environmental influences on depressive symptoms across adolescence and young adulthood.
作者信息
Lau Jennifer Y F, Eley Thalia C
机构信息
Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health,15K North Drive, Room 211, Bethesda, MD 20892-2670, USA.
出版信息
Br J Psychiatry. 2006 Nov;189:422-7. doi: 10.1192/bjp.bp.105.018721.
BACKGROUND
Depression rises markedly in adolescence, a time when increased and new genetic influences have been reported.
AIMS
To examine'new'and'stable' genetic and environmental factors on depressive symptoms in adolescence and young adulthood.
METHOD
A questionnaire survey investigated a sample of twin and sibling pairs at three time points over an approximately 3-year period. Over 1800 twin and sibling pairs reported depressive symptoms at the three time points. Data were analysed using multivariate genetic models.
RESULTS
Depressive symptoms at all time points were moderately heritable with substantial non-shared environmental contributions. Wave 1 genetic factors accounted for continuity of symptoms at waves 2 and 3. 'New'genetic effects at wave 2 also influenced wave 3 symptoms. New non-shared environmental influences emerged at each time point.
CONCLUSIONS
New genetic and environmental influences may explain age-related increases in depression across development.
背景
抑郁症在青春期显著增加，据报道，这一时期存在新的且不断增加的基因影响因素。
目的
研究青春期和青年期抑郁症状的“新的”和“稳定的”基因及环境因素。
方法
一项问卷调查在大约3年的时间里对双胞胎和兄弟姐妹样本进行了3次调查。超过1800对双胞胎和兄弟姐妹在这3个时间点报告了抑郁症状。使用多变量遗传模型对数据进行分析。
结果
所有时间点的抑郁症状都具有中等程度的遗传性，且有大量非共享环境因素的影响。第1阶段的基因因素导致了第2阶段和第3阶段症状的连续性。第2阶段的“新的”基因效应也影响了第3阶段的症状。在每个时间点都出现了新的非共享环境影响因素。
结论
新的基因和环境影响因素可能解释了整个发育过程中与年龄相关的抑郁症增加现象。
Zotero 插件