Corneal topographic features in a family with nanophthalmos.

PURPOSE

To characterize the corneal topographic features in a family with nanophthalmos.

METHODS

Two observational case reports and a review of the literature. Corneal shape was analyzed using a topographic modeling system (TMS) and an Orbscan topographic system, with further analysis based on Fourier series and Zernicke polynomials. A control group was used for comparison.

RESULTS

Two female family members with nanophthalmos belonging to the same generation showed significant irregular corneal astigmatism and corneal steepening.

CONCLUSION

Topographic corneal steepening and irregular astigmatism seems to be associated in 1 family with inherited nanophthalmos. Higher degrees of irregular astigmatism, which were not evident without a topographic analysis, may account, in part, for the unexplained visual reduction.