Srinivasan Sathish, Batterbury Mark, Marsh Ian B, Fisher Anthony C, Willoughby Colin, Kaye Stephen B
Department of Ophthalmology, Aintree University Hospitals, Liverpool, United Kingdom.
Cornea. 2006 Jul;25(6):750-6. doi: 10.1097/01.ico.0000220770.19402.50.
To characterize the corneal topographic features in a family with nanophthalmos.
Two observational case reports and a review of the literature. Corneal shape was analyzed using a topographic modeling system (TMS) and an Orbscan topographic system, with further analysis based on Fourier series and Zernicke polynomials. A control group was used for comparison.
Two female family members with nanophthalmos belonging to the same generation showed significant irregular corneal astigmatism and corneal steepening.
Topographic corneal steepening and irregular astigmatism seems to be associated in 1 family with inherited nanophthalmos. Higher degrees of irregular astigmatism, which were not evident without a topographic analysis, may account, in part, for the unexplained visual reduction.
