Takami Toshihiro, Ohata Kenji, Goto Takeo, Tsuyuguchi Naohiro, Nishio Akimasa, Hara Mitsuhiro
Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Skull Base. 2006 May;16(2):85-94. doi: 10.1055/s-2006-934109.
In the management of skull base chordomas, surgical treatment is essential to achieve long-term control. A petroclival chordoma growing laterally in the skull base is one of the most challenging tumors for neurosurgeons. We have treated petroclival chordomas based on the principle of maximal surgical resection of the tumor with minimal morbidity. Lateral skull base approaches were used to approach petroclival chordomas in eight patients. The surgical procedure involved removal of soft tumor tissue and extensive drilling of adjacent bony structures. Gross total resection of the tumor was achieved in six patients. Subtotal resection in the remaining two patients was associated with acceptable morbidity. In cases of petroclival chordomas, lateral skull base approaches can be used as a primary procedure, although those approaches may be associated with high rates of morbidity and mortality.
在颅底脊索瘤的治疗中，手术治疗对于实现长期控制至关重要。向颅底外侧生长的岩斜区脊索瘤是神经外科医生面临的最具挑战性的肿瘤之一。我们基于以最小的发病率实现肿瘤最大程度手术切除的原则来治疗岩斜区脊索瘤。采用颅底外侧入路治疗了8例岩斜区脊索瘤患者。手术过程包括切除肿瘤软组织并广泛磨除相邻的骨质结构。6例患者实现了肿瘤全切除。其余2例患者次全切除，其发病率可接受。对于岩斜区脊索瘤病例，颅底外侧入路可作为主要手术方式，尽管这些入路可能伴随着较高的发病率和死亡率。
