Chen Yizhao, Tachibana Osamu, Oda Masashi, Xu Ruxiang, Hamada Jun-Ichiro, Yamashita Junkoh, Hashimoto Nobuo, Takahashi Jun A
Department of Neurosurgery, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan.
J Neurooncol. 2006 Dec;80(3):219-25. doi: 10.1007/s11060-005-9057-1. Epub 2006 Nov 1.
Aquaporins (AQPs) is a water channel family which facilitates the passage of water across cell membranes. Recently, expression of aquapporin 1 (AQP1) was found to be involved in not only water transport but also tumorigenesis. In present study, we analyzed the expression of AQP1 in 26 consecutive cases of human hemangioblastomas. Significant upregulation of AQP1 expression was found in hemangioblastomas compared with control brain (P=0.002). In hemangioblastomas, expression of AQP1 was predominantly localized on membranes of stromal cells. The expression level of AQP1 in cystic group of hemangioblastomas is much higher than that of solid group (P=0.021). Most hemangioblastomas showed a negative expression of AQP1 on endothelial cells. These results imply that increased expression of AQP1 in stromal cells may play a role in cyst formation and tumorigenesis of heman-gioblastomas.
水通道蛋白（AQPs）是一个水通道家族，可促进水穿过细胞膜。最近发现，水通道蛋白1（AQP1）的表达不仅参与水的运输，还与肿瘤发生有关。在本研究中，我们分析了26例连续的人类成血管细胞瘤中AQP1的表达情况。与对照脑相比，成血管细胞瘤中AQP1表达显著上调（P = 0.002）。在成血管细胞瘤中，AQP1的表达主要定位于基质细胞的膜上。成血管细胞瘤囊性组中AQP1的表达水平远高于实性组（P = 0.021）。大多数成血管细胞瘤在内皮细胞上显示AQP1阴性表达。这些结果表明，基质细胞中AQP1表达的增加可能在成血管细胞瘤的囊肿形成和肿瘤发生中起作用。
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