雄激素、雌激素α和β以及孕激素受体在犬前列腺中的表达：正常、炎症、增生和肿瘤性腺之间的差异。

Expression of androgen, oestrogen alpha and beta, and progesterone receptors in the canine prostate: differences between normal, inflamed, hyperplastic and neoplastic glands.

作者信息

Gallardo F, Mogas T, Baró T, Rabanal R, Morote J, Abal M, Reventós J, Lloreta J

机构信息

Departament de Medicina i Cirurgia Animals, Facultat de Veterinaria, Universitat Autònoma de Barcelona, Barcelona, Spain.

出版信息

J Comp Pathol. 2007 Jan;136(1):1-8. doi: 10.1016/j.jcpa.2006.08.007. Epub 2006 Oct 31.

DOI:10.1016/j.jcpa.2006.08.007

PMID:17078963

Abstract

The expression of receptor for androgen (AR), oestrogen alpha and beta (ERalpha and ERbeta) and progesterone (PR) was examined immunohistochemically in canine prostate specimens (normal, hyperplastic, inflamed [prostatitis] or neoplastic). AR immunolabelling was seen in 100% of epithelial cells of normal and hyperplastic tissue, the corresponding figures for inflamed and carcinomatous tissue being 74% and 65%, respectively. ERalpha labelling was seen in 85% of epithelial cells in normal prostate glands, the corresponding figures for hyperplastic, inflamed and neoplastic glands being 35%, 22% and 12%, respectively. ERbeta labelling was seen in 85% of epithelial cells of normal glands and in about 70% of such cells in glands showing pathological changes. On the other hand, PR expression (weak) in normal glands was observed in fewer epithelial cells (44%) than in hyperplastic (70%), inflamed (62%) or neoplastic (64%) glands.

摘要

采用免疫组织化学方法检测了犬前列腺标本（正常、增生、炎症[前列腺炎]或肿瘤）中雄激素受体（AR）、雌激素α和β（ERα和ERβ）以及孕激素受体（PR）的表达情况。在正常和增生组织的100%上皮细胞中可见AR免疫标记，炎症组织和癌组织中的相应比例分别为74%和65%。在正常前列腺腺上皮细胞的85%中可见ERα标记，增生、炎症和肿瘤性腺上皮细胞中的相应比例分别为35%、22%和12%。在正常腺上皮细胞的85%以及出现病理变化的腺上皮细胞的约70%中可见ERβ标记。另一方面，正常腺体中PR表达（较弱）在上皮细胞中的比例（44%）低于增生（70%）、炎症（62%）或肿瘤（64%）腺体。