Golubchik Pavel, Lewis Matthew, Maayan Rachel, Sever Jonathan, Strous Rael, Weizman Abraham
Child and Adolescent Outpatient Unit, Geha Mental Health Center, Petah Tiqva, Israel.
Eur Neuropsychopharmacol. 2007 Feb;17(3):157-64. doi: 10.1016/j.euroneuro.2006.08.003. Epub 2006 Oct 31.
Neurosteroids play a significant role in neurodevelopment and are involved in a wide variety of psychopathological processes. There is accumulating evidence on their role in adult psychopathology, including Alzheimer disease, schizophrenia, mood disorder, anxiety disorders and post-traumatic stress disorder. Little is known, however, about the possible role of neurosteroids in child and adolescent psychopathology although there is increasing evidence for their critical role from the early stages of brain development until adolescence. In this review we focus on the involvement of neurosteroids in neurodevelopment and mental disorders in children and adolescents. Adequate physiological levels protect the developing neural system from insult and contribute to the regulation of brain organization and function. Neurosteroids may be involved in the pathophysiology and pharmacotherapy of a variety of disorders in children and adolescents, including schizophrenia, depression, eating disorders, aggressive behavior and attention deficit. The complex interaction between neurosteroids, neurodevelopment, life-events, genetics and mental disorders in children and adolescents merits further investigation.
神经甾体在神经发育中发挥着重要作用，并参与多种精神病理过程。关于它们在成人精神病理学中的作用，包括阿尔茨海默病、精神分裂症、情绪障碍、焦虑症和创伤后应激障碍，有越来越多的证据。然而，尽管有越来越多的证据表明神经甾体从大脑发育早期到青春期都起着关键作用，但对于它们在儿童和青少年精神病理学中的可能作用却知之甚少。在这篇综述中，我们关注神经甾体在儿童和青少年神经发育及精神障碍中的作用。适当的生理水平可保护发育中的神经系统免受损伤，并有助于调节脑组织和功能。神经甾体可能参与儿童和青少年多种疾病的病理生理学和药物治疗，包括精神分裂症、抑郁症、饮食失调、攻击行为和注意力缺陷。神经甾体、神经发育、生活事件、遗传学和儿童及青少年精神障碍之间的复杂相互作用值得进一步研究。
