意外发现新型咪唑并吡唑骨架作为选择性雄激素受体调节剂。
Serendipitous discovery of novel imidazolopyrazole scaffold as selective androgen receptor modulators.
作者信息
Zhang Xuqing, Li Xiaojie, Allan George F, Sbriscia Tifanie, Linton Olivia, Lundeen Scott G, Sui Zhihua
机构信息
Drug Discovery, Johnson & Johnson Pharmaceutical Research and Development, LLC, 665 Stockton Drive, Exton, PA 19341, USA.
出版信息
Bioorg Med Chem Lett. 2007 Jan 15;17(2):439-43. doi: 10.1016/j.bmcl.2006.10.035. Epub 2006 Oct 17.
PMID:17079140
Abstract
A novel imidazolopyrazole derivative has been fortuitously discovered as potent selective androgen receptor modulator with in vivo efficacy.
摘要
一种新型咪唑并吡唑衍生物被意外发现是一种具有体内活性的强效选择性雄激素受体调节剂。
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