Novel nucleotide triphosphates as potent P2Y2 agonists with enhanced stability over UTP.
作者信息
Davenport Richard J, Diaz Paloma, Galvin Frances C A, Lloyd Steve, Mack Stephen R, Owens Ray, Sabin Verity, Wynn Joanne
机构信息
UCB-Group, Granta Park, Abington, Cambridge CB1 6GS, UK.
出版信息
Bioorg Med Chem Lett. 2007 Jan 15;17(2):558-61. doi: 10.1016/j.bmcl.2006.10.038. Epub 2006 Oct 19.
PMID:17079144
Abstract
The synthesis of a series of novel C-linked nucleotide triphosphates is reported. These exhibit excellent agonist potency and selectivity for the P2Y2 receptor with a number of examples having EC50 values below 10 nM. Representative compounds from the N-linked and C-linked series showed enhanced metabolic stability compared with that of the natural ligand UTP.
摘要
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