病毒微小RNA在爱泼斯坦-巴尔病毒相关胃癌中的表达
Expression of viral microRNAs in Epstein-Barr virus-associated gastric carcinoma.
作者信息
Kim Do Nyun, Chae Hiun-Suk, Oh Sang Taek, Kang Jin-Hyoung, Park Cho Hyun, Park Won Sang, Takada Kenzo, Lee Jae Myun, Lee Won-Keun, Lee Suk Kyeong
机构信息
Research Institute of Immunobiology, Catholic University of Korea, Seoul, Korea.
出版信息
J Virol. 2007 Jan;81(2):1033-6. doi: 10.1128/JVI.02271-06. Epub 2006 Nov 1.
Abstract
Epstein-Barr virus (EBV) is associated with about 6 to 16% of gastric carcinoma cases worldwide. Expression of the EBV microRNAs (miRNAs) was observed in B cells and nasopharyngeal carcinoma cells infected with EBV. However, it is not clear if the EBV miRNAs are expressed in EBV-associated gastric carcinomas (EBVaGCs). We found that BART miRNAs but not BHRF1 miRNAs were expressed in EBV-infected gastric carcinoma cell lines and the tumor tissues from patients as well as the animal model. The expression of viral miRNAs in EBVaGCs suggests that these EBV miRNAs may play important roles in the tumorigenesis of EBVaGCs.
摘要
爱泼斯坦-巴尔病毒（EBV）与全球约6%至16%的胃癌病例相关。在感染EBV的B细胞和鼻咽癌细胞中观察到EBV微小RNA（miRNA）的表达。然而，尚不清楚EBV miRNA是否在EBV相关胃癌（EBVaGC）中表达。我们发现，BART miRNA而非BHRF1 miRNA在EBV感染的胃癌细胞系、患者的肿瘤组织以及动物模型中均有表达。EBVaGC中病毒miRNA的表达表明，这些EBV miRNA可能在EBVaGC的肿瘤发生中发挥重要作用。
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