Tanaka Yoshiya
University of Occupational and Environmental Health, School of Medicine, The First Department of Internal Medicine.
Clin Calcium. 2006 Nov;16(11):1858-65.
Glucocorticoid (GC) is widely used to treat a variety of inflammatory and allergic diseases and about one million people in Japan are known to take oral GC. GC causes a number of significant side effects and among them osteoporosis and degenerative bone fracture are major complications of GC therapy. However, few physicians are aware of the increased risk of fracture caused by GC, and there is inadequate information concerning the effectiveness of prevention and treatment of GC-induced osteoporosis. Recent multiple evidence strongly indicates that bisphosphonate is effective for treatment and prophylaxis of GC-induced osteoporosis by improving both quantity and quality of bones, which results in reduction of the proportion of fractures.
糖皮质激素（GC）被广泛用于治疗各种炎症和过敏性疾病，在日本约有100万人服用口服GC。GC会引发许多严重的副作用，其中骨质疏松和退行性骨折是GC治疗的主要并发症。然而，很少有医生意识到GC会增加骨折风险，而且关于GC诱导的骨质疏松症的预防和治疗效果的信息也不足。最近的多项证据有力地表明，双膦酸盐通过改善骨骼的数量和质量，对GC诱导的骨质疏松症的治疗和预防有效，从而降低骨折比例。
