Boggio Paulo S, Alonso-Alonso Miguel, Mansur Carlos G, Rigonatti Sergio P, Schlaug Gottfried, Pascual-Leone Alvaro, Fregni Felipe
Center for Non-Invasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
Am J Phys Med Rehabil. 2006 Nov;85(11):927-30. doi: 10.1097/01.phm.0000242635.88129.38.
Previous research has shown that low-frequency rTMS of the unaffected hemisphere can improve motor function in acute and chronic stroke patients. However, these studies only investigated patients with mild or moderate motor deficits. We report a case of a stroke patient with a severe motor impairment who underwent sham and active repetitive transcranial magnetic stimulation (rTMS) of the unaffected hemisphere and had significantly improved motor function after active, but not after sham, stimulation of the unaffected primary motor cortex. In an additional session of active rTMS, this patient maintained and further enhanced the initial motor improvement. This case report shows that inhibitory rTMS of the unaffected hemisphere can also be beneficial for stroke patients with severe motor deficits and suggests that this approach of noninvasive brain stimulation should be further investigated in this population of patients.
先前的研究表明，对未受影响的半球进行低频重复经颅磁刺激（rTMS）可改善急性和慢性中风患者的运动功能。然而，这些研究仅调查了轻度或中度运动障碍的患者。我们报告了一例严重运动障碍的中风患者，该患者接受了对未受影响半球的假刺激和主动重复经颅磁刺激（rTMS），在对未受影响的初级运动皮层进行主动刺激后运动功能显著改善，而假刺激后则无改善。在额外的一次主动rTMS治疗中，该患者维持并进一步增强了最初的运动改善。本病例报告表明，对未受影响的半球进行抑制性rTMS对严重运动障碍的中风患者也可能有益，并表明这种非侵入性脑刺激方法应在这类患者中进一步研究。
