Sizeland P C, Bailey R R, Lynn K L, Robson R A
Department of Nephrology, Christchurch Hospital, New Zealand.
J Cardiovasc Pharmacol. 1990;16 Suppl 7:S117-9.
The renin-angiotensin system has been shown to have an effect on erythropoietin synthesis and hemoglobin concentration. We present a retrospective study of stable renal transplant recipients who received an angiotensin-converting enzyme (ACE) inhibitor as treatment of hypertension. Fifteen patients were eligible, with a mean hemoglobin concentration of 130.7 +/- 22.7 g/L (SD). Within 6 months of ACE-inhibitor therapy, the mean hemoglobin had fallen significantly to 110.5 +/- 23.2 g/L (p less than 0.001). No parallel change in leukocyte or platelet counts was evident. Prospective studies are needed to clarify the effect of inhibition of the renin-angiotensin system on erythropoietin synthesis and release.
肾素-血管紧张素系统已被证明对促红细胞生成素的合成和血红蛋白浓度有影响。我们对接受血管紧张素转换酶（ACE）抑制剂治疗高血压的稳定肾移植受者进行了一项回顾性研究。15名患者符合条件，平均血红蛋白浓度为130.7±22.7 g/L（标准差）。在ACE抑制剂治疗的6个月内，平均血红蛋白显著降至110.5±23.2 g/L（p<0.001）。白细胞或血小板计数没有明显的平行变化。需要进行前瞻性研究以阐明抑制肾素-血管紧张素系统对促红细胞生成素合成和释放的影响。
