Soliman A S, Tackett R L
Cardiovascular Pharmacodynamic Lab, College of Pharmacy, University of Georgia, Athens 30602.
J Cardiovasc Pharmacol. 1991 Jan;17(1):154-7. doi: 10.1097/00005344-199101000-00022.
This study was designed to investigate early changes in reactivity in relation to the adrenergic innervation of venous grafts. Saphenous vein grafts were implanted into the carotid artery by the end-to-end technique in mongrel dogs. After 1 week, the grafts were harvested and dose-response curves to norepinephrine and tyramine were determined and compared with those of nongrafted saphenous veins and carotid arteries. Tissue norepinephrine levels of the blood vessels were measured by HPLC with electrochemical detection. Grafted vessels demonstrated an enhanced sensitivity to norepinephrine and a significant attenuation to tyramine. Additionally, grafted saphenous veins exhibited a significant depletion of norepinephrine content when compared to nongrafted veins. These differences suggest that denervation of the saphenous vein produces a supersensitivity to catecholamines that could account for enhanced vascular reactivity observed following implantation of saphenous vein grafts.
本研究旨在调查与静脉移植物肾上腺素能神经支配相关的反应性早期变化。采用端端技术将大隐静脉移植物植入杂种犬的颈动脉。1周后，取出移植物，测定去甲肾上腺素和酪胺的剂量反应曲线，并与未移植的大隐静脉和颈动脉的曲线进行比较。采用高效液相色谱电化学检测法测量血管组织中的去甲肾上腺素水平。移植血管对去甲肾上腺素的敏感性增强，对酪胺的反应明显减弱。此外，与未移植的静脉相比，移植的大隐静脉去甲肾上腺素含量显著减少。这些差异表明，大隐静脉去神经支配会导致对儿茶酚胺超敏，这可能解释了大隐静脉移植物植入后观察到的血管反应性增强。
