柱孢环肽A，一种来自柱孢属真菌的新型细胞毒性环肽

Cylindrocyclin A, a new cytotoxic cyclopeptide from Cylindrocarpon sp.

作者信息

Weber Daniela, Erosa Gilda, Sterner Olov, Anke Timm

机构信息

Institute of Biotechnology and Drug Research, Erwin-Schrödinger-Str. 56, D-67663 Kaiserslautern, Germany.

出版信息

J Antibiot (Tokyo). 2006 Aug;59(8):495-9. doi: 10.1038/ja.2006.69.

DOI:10.1038/ja.2006.69

PMID:17080686

Abstract

In the course of a screening of fungal extracts for new metabolites with cytotoxic activities cylindrocyclin A (1) was isolated. The producing strain was identified as Cylindrocarpon sp. by microscopy and ITS rDNA sequence analysis. 1 is a novel compound that exhibits cytotoxic acticity against six different cell lines with IC50 values ranging from 11 to 53 microM. 1 has no antibacterial or antifungal activity. The compound is a cyclic nonapeptide comprising three alanines, five leucines and one isoleucine. Four amino acids are N-methylated. Its structure was elucidated by spectroscopic methods.

摘要

在对具有细胞毒性活性的新型代谢产物的真菌提取物进行筛选的过程中，分离出了圆柱环肽A（1）。通过显微镜检查和ITS rDNA序列分析，将产生该物质的菌株鉴定为柱孢属真菌。1是一种新型化合物，对六种不同的细胞系具有细胞毒性活性，IC50值范围为11至53微摩尔。1没有抗菌或抗真菌活性。该化合物是一种环状九肽，由三个丙氨酸、五个亮氨酸和一个异亮氨酸组成。四个氨基酸被N-甲基化。其结构通过光谱方法得以阐明。