Huwiler Andrea, Pfeilschifter Josef
Pharmazentrum Frankfurt, Klinikum der Johann-Wolfgang-Goethe-Universität, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany.
Biol Chem. 2006 Oct-Nov;387(10-11):1321-8. doi: 10.1515/BC.2006.165.
Sufficient oxygen supply is crucial for the development and physiology of mammalian cells and tissues. When simple diffusion of oxygen becomes inadequate to provide the necessary flow of substrate, evolution has provided cells with tools to detect and respond to hypoxia by upregulating the expression of specific genes, which allows an adaptation to hypoxia-induced stress conditions. The modulation of cell signaling by hypoxia is an emerging area of research that provides insight into the orchestration of cell adaptation to a changing environment. Cell signaling and adaptation processes are often accompanied by rapid and/or chronic remodeling of membrane lipids by activated lipases. This review highlights the bi-directional relation between hypoxia and lipid signaling mechanisms.
充足的氧气供应对于哺乳动物细胞和组织的发育及生理功能至关重要。当氧气的简单扩散不足以提供必要的底物流动时，进化为细胞提供了通过上调特定基因的表达来检测和应对缺氧的工具，从而使细胞能够适应缺氧诱导的应激条件。缺氧对细胞信号传导的调节是一个新兴的研究领域，它为深入了解细胞对不断变化的环境的适应协调机制提供了线索。细胞信号传导和适应过程通常伴随着活化脂肪酶对膜脂的快速和/或慢性重塑。本综述重点介绍了缺氧与脂质信号传导机制之间的双向关系。
