氨基酸序列甘氨酸-丙氨酸-脯氨酸-亮氨酸似乎是血小板整合素糖蛋白IIb中的一个纤维蛋白原结合位点。
The amino acid sequence Gly-Ala-Pro-Leu appears to be a fibrinogen binding site in the platelet integrin, glycoprotein IIb.
作者信息
Gartner T K, Taylor D B
机构信息
Department of Biology, Memphis State University, TN 38152.
出版信息
Thromb Res. 1990 Nov 15;60(4):291-309. doi: 10.1016/0049-3848(90)90108-o.
The amino acid sequence Gly-Ala-Pro-Leu-Arg-Val is predicted by the anticomplementarity hypothesis to be a fibrinogen binding site on human platelet fibrinogen receptors. The peptide Ala-Pro-Leu-Arg-Val binds fibrinogen and inhibits platelet aggregation and clot retraction. The peptide Gly-Ala-Pro-Leu is the shortest sequence within the predicted sequence which potently inhibits the adhesion of platelets to fibrinogen and platelet aggregation. The sequence Gly-Ala-Pro-Leu is present as residues 309-312 in glycoprotein IIb, the alpha-subunit of the glycoprotein IIb/IIIa complex, the fibrinogen receptor. The sequence Gly-Ala-Pro-Leu is present in 4 of 8 integrin alpha-subunits and Gly-Ala-Pro is present in 8 of 8 integrin alpha-subunits.
根据反互补性假说预测，氨基酸序列甘氨酸-丙氨酸-脯氨酸-亮氨酸-精氨酸-缬氨酸是人血小板纤维蛋白原受体上的一个纤维蛋白原结合位点。肽段丙氨酸-脯氨酸-亮氨酸-精氨酸-缬氨酸能结合纤维蛋白原，并抑制血小板聚集和凝块回缩。肽段甘氨酸-丙氨酸-脯氨酸-亮氨酸是预测序列中能有效抑制血小板与纤维蛋白原黏附及血小板聚集的最短序列。序列甘氨酸-丙氨酸-脯氨酸-亮氨酸作为糖蛋白IIb（糖蛋白IIb/IIIa复合物的α亚基，即纤维蛋白原受体）中的第309 - 312位残基存在。序列甘氨酸-丙氨酸-脯氨酸-亮氨酸存在于8个整合素α亚基中的4个，而甘氨酸-丙氨酸-脯氨酸存在于所有8个整合素α亚基中。
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