蠕虫清除了围绕尼古丁成瘾的迷雾。

Worms clear the smoke surrounding nicotine addiction.

作者信息

Kelley Ann E

机构信息

Department of Psychiatry, University of Wisconsin-Madison, 6001 Research Park Boulevard, Madison, WI 53705, USA.

出版信息

Cell. 2006 Nov 3;127(3):460-2. doi: 10.1016/j.cell.2006.10.024.

DOI:10.1016/j.cell.2006.10.024

PMID:17081968

Abstract

In this issue of Cell, Feng et al. report a worm model of nicotine dependence that shows behavioral adaptations surprisingly similar to those in humans. These authors show a critical link between nicotinic receptors and TRP channels, which may represent a new therapeutic target for treating nicotine addiction.

摘要

在本期《细胞》杂志中，冯等人报道了一种尼古丁依赖的线虫模型，该模型显示出与人类惊人相似的行为适应性。这些作者揭示了烟碱受体与瞬时受体电位（TRP）通道之间的关键联系，这可能代表了治疗尼古丁成瘾的一个新的治疗靶点。