Barbay Scott, Zoubina Elena V, Dancause Numa, Frost Shawn B, Eisner-Janowicz Ines, Stowe Ann M, Plautz Erik J, Nudo Randolph J
Landon Center on Aging and Department of Molecular and Integrative Physiology and the University of Kansas Medical Center, Kansas City, KS 66160, USA.
Neurorehabil Neural Repair. 2006 Dec;20(4):455-8. doi: 10.1177/1545968306290773.
There is growing interest in the use of D-amphetamine (D-AMPH) as a pharmacological treatment to supplement rehabilitative therapy following stroke. Based on the success of earlier animal models, several clinical studies have demonstrated beneficial effects of applying physical rehabilitation while stroke patients are under the influence of D-AMPH. To begin to understand the neural mechanisms underlying this promising adjuvant therapy, the authors examined the effects of a single pairing of D-AMPH and rehabilitative training on motor performance after cortical infarct in squirrel monkeys.
Microelectrode stimulation techniques were used to delineate hand movement areas in the primary motor cortex prior to delivering a unilateral infarct to the complete hand representation. Postinfarct recovery was assessed for 3 groups of monkeys: D-AMPH + training, saline + training, and spontaneous recovery (SR). Postinfarct training groups received 14 consecutive days of motor skill training on a reach and retrieval task. A single injection of D-AMPH (0.25 mg/kg) or saline was given only on the 1st day of training (postinfarct day 10). Monkeys in the SR group had only minimal exposure to the training task once per week to monitor recovery.
The results show that a single coupling of D-AMPH + training initiated 10 days after cortical infarct facilitated the rate of recovery and improved performance (68% improvement from 1st day of training) beyond the level achieved by the monkeys in the saline + training group (27% improved from 1st day of training).
D-AMPH is a potent modulator of behavioral recovery following an ischemic infarct in nonhuman primates.
作为一种药物治疗手段，使用右旋苯丙胺（D-AMPH）辅助中风后的康复治疗正受到越来越多的关注。基于早期动物模型取得的成功，多项临床研究表明，在中风患者接受D-AMPH影响的同时进行物理康复治疗具有有益效果。为了初步了解这种有前景的辅助治疗背后的神经机制，作者研究了单次将D-AMPH与康复训练配对对松鼠猴皮质梗死后运动表现的影响。
在对完整手部代表区进行单侧梗死之前，使用微电极刺激技术描绘初级运动皮层中的手部运动区域。对3组猴子进行梗死后恢复评估：D-AMPH +训练组、生理盐水+训练组和自发恢复组（SR）。梗死后训练组连续14天接受针对伸手取物任务的运动技能训练。仅在训练的第1天（梗死后第10天）单次注射D-AMPH（0.25 mg/kg）或生理盐水。SR组的猴子每周仅极少地接触一次训练任务以监测恢复情况。
结果显示，在皮质梗死后10天开始的单次D-AMPH +训练配对促进了恢复速度并改善了表现（从训练第一天起提高了68%），超过了生理盐水+训练组猴子所达到的水平（从训练第一天起提高了27%）。
D-AMPH是一种对非人类灵长类动物缺血性梗死后行为恢复有强大调节作用的物质。
