Aybek Hulya, Aybek Zafer, Sinik Zafer, Demir Suleyman, Sancak Burak, Tuncay Levent
Department of Biochemistry, Pamukkale University School of Medicine, Denizli, Turkey.
Int J Urol. 2006 Nov;13(11):1380-4. doi: 10.1111/j.1442-2042.2006.01593.x.
The aim of this study was to find out the predictive role of serum and urinary carbohydrate antigen 19-9 levels in benign hydronephrosis and whether these levels are helpful for differentiation of complete or partial urinary obstruction.
Fifty-four patients with, and 23 without, benign hydronephrosis were enrolled in this study. Serum and urinary carbohydrate antigen 19-9 were determined by the chemiluminescence enzyme immunometric assay method and these levels were correlated with clinical factors.
The mean serum (P < 0.0001) and urinary (P < 0.0001) carbohydrate antigen 19-9 and serum creatinine (P < 0.008) levels were significantly higher in the hydronephrosis group than the control group. There was significant correlation between serum and urinary carbohydrate antigen 19-9 levels in the hydronephrosis group (r = 0.639, P < 0.0001). In the hydronephrosis group, there were no significant differences between the serum creatinine, serum or urinary carbohydrate antigen 19-9 levels and the clinical features except symptom duration. The best cut-off value for the serum and urinary carbohydrate antigen 19-9 were found to be 4.84 U/mL and 29.35 U/mL, respectively.
Serum and urinary carbohydrate antigen 19-9 levels correlated with each other, were significantly elevated in patients with hydronephrosis and did not predict complete urinary obstruction. Benign hydronephrosis should be considered in the differential diagnosis of carbohydrate antigen 19-9 increments, as this is what is of most importance in clinical practice.
本研究旨在探讨血清和尿中糖类抗原19-9水平在良性肾积水诊断中的预测作用，以及这些水平是否有助于鉴别完全性或部分性尿路梗阻。
本研究纳入了54例患有良性肾积水的患者和23例未患良性肾积水的患者。采用化学发光酶免疫分析法测定血清和尿中糖类抗原19-9水平，并将这些水平与临床因素进行相关性分析。
肾积水组患者的血清（P < 0.0001）和尿（P < 0.0001）糖类抗原19-9以及血清肌酐水平（P < 0.008）显著高于对照组。肾积水组患者的血清和尿糖类抗原19-9水平之间存在显著相关性（r = 0.639，P < 0.0001）。在肾积水组中，除症状持续时间外，血清肌酐、血清或尿糖类抗原19-9水平与临床特征之间无显著差异。血清和尿糖类抗原19-9的最佳截断值分别为4.84 U/mL和29.35 U/mL。
血清和尿糖类抗原19-9水平相互关联，在肾积水患者中显著升高，但不能预测完全性尿路梗阻。在糖类抗原19-9升高的鉴别诊断中应考虑良性肾积水，因为这在临床实践中最为重要。
