Aissa-Fennira F B, Benammar-Elgaaied A, Bouguerra A, Schmitt C, Brouet J C, Dellagi K
Laboratory of Hematology and Immunopathology, Faculté de Médecine de Tunis, Tunisie.
Eur J Immunol. 1991 Apr;21(4):1065-8. doi: 10.1002/eji.1830210431.
One hundred and thirteen sera from patients with monoclonal IgG were tested for reactivity against a panel of 13 human monoclonal IgM having various autoantibody activities: 6 to myelin-associated glycoprotein (MAG), 2 to vimentin intermediate filament protein and 5 to red blood cell antigens [cold agglutinins with specificity directed to I antigen (3 cases), i antigen (1 case) or Pr antigen (1 case)]. One IgG was found to react with a monoclonal IgM with anti-MAG activity. This reactivity was characterized as idiotypic and directed against a private idiotope of the monoclonal IgM. This work provides further evidence for the existence of anti-idiotypic antibody activity of monoclonal Ig occurring in human B cell neoplasias.
对113份来自单克隆IgG患者的血清进行检测，以观察其与一组13种具有不同自身抗体活性的人单克隆IgM的反应性：其中6种针对髓鞘相关糖蛋白（MAG），2种针对波形蛋白中间丝蛋白，5种针对红细胞抗原[具有针对I抗原（3例）、i抗原（1例）或Pr抗原（1例）特异性的冷凝集素]。发现一种IgG与具有抗MAG活性的单克隆IgM发生反应。这种反应性被表征为独特型，并针对单克隆IgM的一个私有独特位。这项工作为人类B细胞肿瘤中出现的单克隆Ig的抗独特型抗体活性的存在提供了进一步的证据。
