The present article examines how individual and situational differences in individuals' regulatory focus on nurturance and gain (promotion) and on security and safety (prevention) may have significant, and distinct, social and interpersonal implications. We first review recent research examining how significant others affect goal pursuit and how individual differences in regulatory focus may moderate the various behavioral, evaluative, and experiential manifestations of social identification. We then consider how regulatory focus moderates the way in which people "size up" their social world in terms of the efficiency in which they identify and appraise motivationally relevant aspects of their social environment. Finally, we explore how regulatory focus moderates people's deliberate and automatic reactions to the beliefs, expectations, behavior, and emotions of other individuals and social groups.