[胚胎移植深度对体外受精-胚胎移植妊娠结局的影响]

[Influence of the depth of embryo transfer on pregnancy outcome in in vitro fertilization-embryo transfer].

作者信息

Luo Jia, Xu Yan-wen, Zhou Can-quan, Fang Cong, Zhang Min-fang, Zhuang Guang-lun

机构信息

Reproductive Research Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.

出版信息

Zhonghua Fu Chan Ke Za Zhi. 2006 Aug;41(8):533-6.

PMID:17083837

Abstract

OBJECTIVE

To detect whether the depth of embryo transfer has influence on pregnancy outcome in in vitro fertilization-embryo transfer (IVF-ET).

METHODS

The distance between the high echogenic transfer dot and the fundal endometrium was measured under guidance of transabdominal ultrasound. The average distance 0.75 cm was used to divide patients into two groups. Group 1 included 44 patients with a distance > 0.75 cm, while group 2 had 48 patients with a distance </= 0.75 cm.

RESULTS

There were no significant differences in the average age (32 +/- 3 versus 31 +/- 4), the mean number of oocytes retrieved (14 +/- 7 versus 14 +/- 6), and the mean number of embryos transferred (2.3 +/- 0.6 versus 2.2 +/- 0.5) between groups 1 and 2. The distance to the fundal endometrium in group 2 was (0.50 +/- 0.21) cm, significantly smaller than that of group 1 (1.02 +/- 0.21) cm (P < 0.01). However, pregnancy rate was significantly higher (P < 0.05) in group 2 (58.3%, 28/48) than in group 1 (36.4%, 16/44). Although implantation rate in group 2 (33.0%, 35/106) was higher than group 1 (22.2%, 22/99), the difference was not significant.

CONCLUSION

Pregnancy outcome may be affected by the depth of embryo transfer, and the fundal endometrium is a favorable region for embryo deposition.

摘要

目的

检测胚胎移植深度对体外受精-胚胎移植（IVF-ET）妊娠结局是否有影响。

方法

在经腹超声引导下测量高回声移植点与宫底子宫内膜之间的距离。以平均距离0.75 cm将患者分为两组。第1组包括44例距离>0.75 cm的患者，第2组有48例距离≤0.75 cm的患者。

结果

第1组和第2组在平均年龄（32±3岁与31±4岁）、平均获卵数（14±7个与14±6个）以及平均移植胚胎数（2.3±0.6个与2.2±0.5个）方面无显著差异。第2组至宫底子宫内膜的距离为（0.50±0.21）cm，显著小于第1组的（1.02±0.21）cm（P<0.01）。然而，第2组的妊娠率（58.3%，28/48）显著高于第1组（36.4%，16/44）（P<0.05）。虽然第2组的着床率（33.0%，35/106）高于第1组（22.2%，22/99），但差异不显著。