Södersten P, Bergh C, Zandian M
Section of Applied Neuroendocrinology, Mandometer Clinic, Karolinska Institutet, AB Mando, Novum, S-141 57 Huddinge, Sweden.
Psychoneuroendocrinology. 2006 Nov;31(10):1149-53. doi: 10.1016/j.psyneuen.2006.09.006. Epub 2006 Nov 2.
It is suggested that the symptoms of anorexia nervosa are physiological responses to starvation. There is no evidence of a neural or non-neural dysfunction that predisposes women for anorexia nervosa and the endocrine and psychological consequences of starvation are reversed once patients have re-learnt how to eat and regained a normal body weight. Because variability in the supply of food may be a common evolutionary condition, it is more likely that body weight is variable than constant in normal circumstances. The role of the neuroendocrine system in times of feast and famine is to allow the individual to adopt behavioral strategies as needed rather than maintaining body weight homeostasis. Treatment of anorexic patients should aim at reducing their high level of physical activity in order to facilitate eating.
有人认为神经性厌食症的症状是对饥饿的生理反应。没有证据表明存在使女性易患神经性厌食症的神经或非神经功能障碍，而且一旦患者重新学会如何进食并恢复正常体重，饥饿带来的内分泌和心理影响就会逆转。由于食物供应的变化可能是一种常见的进化状况，在正常情况下体重更有可能是可变的而非恒定不变。神经内分泌系统在丰衣足食和饥馑时期的作用是让个体根据需要采取行为策略，而非维持体重的稳态。厌食症患者的治疗应以减少其高强度身体活动为目标，以便于进食。
