van Brakel Richard W, Eygendaal Denise
Department of Orthopaedics, Amphia Hospital, Breda, The Netherlands.
Arthroscopy. 2006 Nov;22(11):1199-203. doi: 10.1016/j.arthro.2006.07.023.
In this study we evaluated the effect and safety of intra-articular injection of hyaluronic acid in 19 consecutive elbows with post-traumatic osteoarthritis.
In 18 patients (10 male and 8 female patients; mean age, 45.6 years [SD, 15.0 years]), 3 injections of sodium hyaluronate were given within 4 weeks at regular intervals. Evaluation took place just before the first injection, as well as after 3 and 6 months, and consisted of the Elbow Function Assessment Score, the Functional Rating Index of Broberg and Morrey, and the Modified Andrews Elbow Scoring System. Pain was also assessed by means of visual analog scales.
Viscosupplementation resulted in slight, short-term pain relief and a very limited decrease in activity impairment at evaluation after 3 months. After 6 months, no beneficial effects were noticed in any of the 19 injected elbows. Other parameters were not influenced by treatment with viscosupplementation at any time. Systemic or local adverse effects did not occur.
Because the use of viscosupplementation for the treatment of post-traumatic osteoarthritis of the elbow provides only slight, short-term pain relief and a very limited decrease in activity impairment and the other parameters were not modified, we believe that viscosupplementation is not suitable for this indication.
Level IV, therapeutic case series.
在本研究中，我们评估了关节内注射透明质酸对19例连续性创伤后创伤性骨关节炎肘关节的疗效和安全性。
18例患者（10例男性和8例女性患者；平均年龄45.6岁[标准差15.0岁]），在4周内每隔一段时间进行3次透明质酸钠注射。在首次注射前、3个月和6个月后进行评估，评估内容包括肘关节功能评估评分、Broberg和Morrey功能评定指数以及改良安德鲁斯肘关节评分系统。疼痛也通过视觉模拟量表进行评估。
在3个月后的评估中，关节内注射透明质酸导致轻微的短期疼痛缓解和活动障碍的非常有限的减轻。6个月后，在19个注射肘关节中均未观察到有益效果。其他参数在任何时候都不受关节内注射透明质酸治疗的影响。未发生全身或局部不良反应。
由于关节内注射透明质酸治疗创伤后创伤性骨关节炎仅提供轻微的短期疼痛缓解和活动障碍的非常有限的减轻，且其他参数未改变，我们认为关节内注射透明质酸不适用于该适应症。
IV级，治疗性病例系列。
