de Swart Rik L, LiCalsi Cynthia, Quirk Alan V, van Amerongen Geert, Nodelman Vladislav, Alcock Robert, Yüksel Selma, Ward Gary H, Hardy John G, Vos Helma, Witham Clyde L, Grainger Christopher I, Kuiken Thijs, Greenspan Bernard J, Gard Trevor G, Osterhaus Albert D M E
Department of Virology, Erasmus MC, Postgraduate School of Molecular Medicine, Rotterdam, The Netherlands.
Vaccine. 2007 Jan 26;25(7):1183-90. doi: 10.1016/j.vaccine.2006.10.019. Epub 2006 Oct 23.
Measles vaccination via the aerosol route has proven effective under field conditions, using vaccine reconstituted prior to nebulization. Inhalation of a dry powder aerosol vaccine would have additional benefits, including easier logistics of administration, reduced cold chain dependence and the potential of single dose administration. We have evaluated two candidate dry powder measles vaccine formulations in macaques. Specific immune responses were demonstrated, but levels of immunity were lower than in animals vaccinated by injection or by nebulized aerosol. These studies provide proof of principle that dry powder inhalation is a possible route for measles vaccination, but suggest that either the vaccine formulation or the method of delivery need to be improved for a better immune response.
在野外条件下，通过雾化途径接种麻疹疫苗已被证明是有效的，所使用的疫苗是在雾化前重新配制的。吸入干粉气溶胶疫苗还有其他好处，包括给药后勤更简便、减少对冷链的依赖以及单剂量给药的可能性。我们在猕猴身上评估了两种候选干粉麻疹疫苗制剂。结果显示了特异性免疫反应，但免疫水平低于通过注射或雾化气溶胶接种疫苗的动物。这些研究提供了原理证明，即干粉吸入是麻疹疫苗接种的一种可能途径，但表明要么疫苗制剂要么给药方法需要改进，以获得更好的免疫反应。
