Micheletti Martina, Lye Gary J
The Advanced Centre for Biochemical Engineering, Department of Biochemical Engineering, University College London, Torrington Place, London WC1E 7JE, UK.
Curr Opin Biotechnol. 2006 Dec;17(6):611-8. doi: 10.1016/j.copbio.2006.10.006. Epub 2006 Nov 3.
Microscale processing techniques offer the potential to speed up the delivery of new drugs to the market, reducing development costs and increasing patient benefit. These techniques have application across both the chemical and biopharmaceutical sectors. The approach involves the study of individual bioprocess operations at the microlitre scale using either microwell or microfluidic formats. In both cases the aim is to generate quantitative bioprocess information early on, so as to inform bioprocess design and speed translation to the manufacturing scale. Automation can enhance experimental throughput and will facilitate the parallel evaluation of competing biocatalyst and process options.
微尺度加工技术有可能加快新药上市的速度，降低研发成本并增加患者受益。这些技术在化学和生物制药领域均有应用。该方法涉及使用微孔板或微流控形式在微升规模上研究单个生物过程操作。在这两种情况下，目的都是尽早生成定量的生物过程信息，以便为生物过程设计提供依据并加快向生产规模的转化。自动化可以提高实验通量，并将有助于对相互竞争的生物催化剂和工艺选项进行并行评估。
