Syka Josef, Ouda Ladislav, Nachtigal Petr, Solichová Dagmar, Semecký Vladimír
Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Vídenská 1083, 14220 Prague, Czech Republic.
Neurosci Lett. 2007 Jan 10;411(2):112-6. doi: 10.1016/j.neulet.2006.10.032. Epub 2006 Nov 7.
Statins have revolutionized the treatment of hypercholesterolemia due to their ability to inhibit cholesterol biosynthesis. Their immunomodulatory and anti-inflammatory effects and positive effects on the treatment of atherosclerosis and its complications are well known. Here, we describe the effects of statins on the treatment of presbycusis in C57BL/6J mice. In this strain with accelerated aging, we demonstrate that animals treated with atorvastatin (10mg/kg per day in chow diet) for 2 months showed larger amplitudes of distortion product otoacoustic emissions (DPOAE) than did the non-treated control group. This finding indicates a better survival of outer hair cell function in the inner ear of C57BL/6J mice. The observed decreased expression of intercellular and vascular adhesion molecules in the aortic wall of atorvastatin-treated animals suggests that reducing endothelial inflammatory effects may contribute to the positive effect of atorvastatin on the amplitudes of DPOAE by influencing the blood supply to the inner ear. No such beneficial effect of statins was found in apoE(-/-) mice treated with atorvastatin under the same conditions. Our results suggest that statins could also slow down the age-related deterioration of hearing in man.
他汀类药物因其抑制胆固醇生物合成的能力，彻底改变了高胆固醇血症的治疗方式。它们的免疫调节和抗炎作用以及对动脉粥样硬化及其并发症治疗的积极作用是众所周知的。在此，我们描述他汀类药物对C57BL/6J小鼠老年性聋治疗的影响。在这种加速衰老的品系中，我们证明，用阿托伐他汀（在饲料中每天10mg/kg）治疗2个月的动物，其畸变产物耳声发射（DPOAE）的幅度比未治疗的对照组更大。这一发现表明C57BL/6J小鼠内耳外毛细胞功能的存活情况更好。在阿托伐他汀治疗的动物主动脉壁中观察到细胞间和血管黏附分子表达降低，这表明减少内皮炎症效应可能通过影响内耳的血液供应，对阿托伐他汀对DPOAE幅度的积极作用有所贡献。在相同条件下用阿托伐他汀治疗的载脂蛋白E基因敲除（apoE(-/-)）小鼠中未发现他汀类药物的这种有益作用。我们的结果表明，他汀类药物也可能减缓人类与年龄相关的听力衰退。
