Fritsch R S, Maschek H, Ehlerding C, Widjaja W, Choritz H, Georgii A
Pathologisches Institut, Medizinischen Hochschule Hannover.
Verh Dtsch Ges Pathol. 1990;74:216-9.
This pilot study comprises quantitative ultrastructural investigations of the normal, non-leukemic granulopoiesis in the bone marrow of four patients suffering from heart diseases, compared with the granulopoiesis of four patients with different types of CMPD. By evaluation of the morphometric parameters it could be demonstrated that normal granulopoiesis is subject to a strong functional order of organelles in the course of maturation, aiming at the preparation of mitoses of immature cells and the production of functionally capable specific granules. Contrary to this, the studied cases of CMPD exhibited striking differences of morphometric parameters, which may be interpreted as functional deficiencies or defects of organelles involved in the production of specific granules, with the phenomenon of dissociation of nuclear and cytoplasmic maturation.
这项初步研究包括对四名心脏病患者骨髓中正常、非白血病性粒细胞生成进行定量超微结构研究，并与四名不同类型慢性髓性增殖性疾病（CMPD）患者的粒细胞生成进行比较。通过对形态计量学参数的评估可以证明，正常粒细胞生成在成熟过程中细胞器遵循强烈的功能顺序，目的是为未成熟细胞的有丝分裂做准备以及产生具有功能的特异性颗粒。与此相反，所研究的CMPD病例表现出形态计量学参数的显著差异，这可解释为参与特异性颗粒产生的细胞器存在功能缺陷或故障，伴有核与细胞质成熟解离的现象。
