Welte K
Abteilung für Pädiatrische Hämatologie und Onkologie, Zentrum Kinderheilkunde der Medizinischen Hochschule Hannover.
Verh Dtsch Ges Pathol. 1990;74:25-7.
Normal hematopoiesis is regulated by a family of hematopoietic growth factors that mediate the proliferation and maturation of blood cell precursors and pluripotential stem cells. Several of these factors have been isolated, biochemically characterized and are now being produced by recombinant DNA techniques in quantities sufficient for preclinical studies and clinical use. Three factors in particular have recently received considerable attention for their potential clinical use: granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF) and Multi-CSF or Interleukin 3 (IL-3). G-CSF is apparently lineage-specific for the proliferation of and differentiation of neutrophil granulocyte precursors. GM-CSF and IL-3 are less restricted in their action, affecting various lineages, such as eosinophil granulocytes, neutrophil granulocytes, monocytes, erythrocytes and megakaryocytes. The CSFs have many potential clinical applications including enhancing granulocyte production and function in neutropenic patients and rendering myeloid leukemic cells more susceptible to killing by cycle-specific agents.
正常造血功能受一类造血生长因子的调节，这些因子介导血细胞前体和多能干细胞的增殖与成熟。其中一些因子已被分离、进行了生化特性鉴定，现在正通过重组DNA技术大量生产，足以用于临床前研究和临床应用。特别是有三种因子最近因其潜在的临床应用而受到相当多的关注：粒细胞-巨噬细胞集落刺激因子（GM-CSF）、粒细胞集落刺激因子（G-CSF）和多能集落刺激因子或白细胞介素3（IL-3）。G-CSF显然对中性粒细胞前体的增殖和分化具有谱系特异性。GM-CSF和IL-3的作用限制较少，可影响多种谱系，如嗜酸性粒细胞、中性粒细胞、单核细胞、红细胞和巨核细胞。集落刺激因子有许多潜在的临床应用，包括提高中性粒细胞减少患者的粒细胞生成和功能，以及使髓系白血病细胞更容易被细胞周期特异性药物杀伤。
