[毛细胞白血病脾脏浸润的表型和基因型特征]
[Phenotypic and genotypic characterization of splenic infiltrates in hairy cell leukemia].
作者信息
Odermatt B F, Knecht H, Bachmann F, Heitz P H
机构信息
Institut für Pathologie, Universitätsspital, Zürich/Schweiz.
出版信息
Verh Dtsch Ges Pathol. 1990;74:359-62.
PMID:1708613
Abstract
Cells of splenic infiltrates of five patients with hairy cell leukemia have been analyzed for the expression of immunoglobulin by immunohistochemistry and for rearrangement of T cell receptor and immunoglobulin genes by the Southern blot technique. In each case surface immunoglobulins were found with monoclonal expression of light chains. Concomitantly, heavy and light chain gene rearrangements were present. These results confirm the B cell nature of hairy cells.
摘要
通过免疫组织化学分析了5例毛细胞白血病患者脾脏浸润细胞免疫球蛋白的表达情况，并采用Southern印迹技术分析了T细胞受体和免疫球蛋白基因的重排情况。在每例患者中均发现表面免疫球蛋白存在轻链的单克隆表达。同时，存在重链和轻链基因重排。这些结果证实了毛细胞的B细胞性质。
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