移植到与间质性水肿相关脑区的神经元细胞的存活及纤维生长。

Survival and fibre outgrowth of neuronal cells transplanted into brain areas associated with interstitial oedema.

作者信息

Tsubokawa T, Katayama Y, Miyazaki S, Ogawa H, Koshinaga M, Ishikawa K

机构信息

Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan.

出版信息

Acta Neurochir Suppl (Wien). 1990;51:265-7. doi: 10.1007/978-3-7091-9115-6_90.

DOI:10.1007/978-3-7091-9115-6_90

PMID:1708646

Abstract

The influence of interstitial oedema on the survival of fetal raphe cells transplanted into serotonin (5-HT)-denervated rats and the fibre outgrowth from these cells was investigated. Fetal raphe cells were transplanted into the corpus callosum in which long-lasting interstitial oedema had been induced by intracisternal kaolin injection. The 5-HT and 5HIAA levels in the corpus callosum were restored to their maximum within 5-6 weeks post-transplantation regardless of whether interstitial oedema was induced or not. Furthermore, it was appeared that the presence of interstitial oedema even facilitated fibre growth as demonstrated by the 5-HT immunohistochemistry and the restoration of the 5-HT and 5-HIAA levels in brain areas distant from the transplantation sites. These results imply favourable effects of interstitial oedema on the survival of transplanted raphe cells and their fibre outgrowth.

摘要

研究了间质水肿对移植到5-羟色胺（5-HT）去神经大鼠体内的胎儿中缝细胞存活以及这些细胞纤维生长的影响。将胎儿中缝细胞移植到经脑池内注射高岭土诱导产生持久间质水肿的胼胝体中。无论是否诱导间质水肿，移植后5-6周内胼胝体中的5-HT和5-羟吲哚乙酸（5HIAA）水平均恢复到最高值。此外，5-HT免疫组化以及远离移植部位的脑区中5-HT和5-HIAA水平的恢复表明，间质水肿的存在甚至促进了纤维生长。这些结果表明间质水肿对移植的中缝细胞存活及其纤维生长具有有利影响。