Shimamoto Chikao, Hirata Ichiro, Tokioka Satoshi, Takeuchi Nozomi, Hiraike Yutaka, Katsu Ken-ichi
Division of Gastroenterology, Department of Internal Medicine II, Osaka Medical College, Japan.
Hepatogastroenterology. 2006 Sep-Oct;53(71):804-6.
BACKGROUND/AIMS: Various studies have indicated a relationship between Helicobacter pylori infection and upper gastrointestinal lesions, but this relationship needs to be assessed in individuals not seeking medical treatment for complaints.
We screened community residents for H. pylori infection and upper gastrointestinal lesions during an annual mass health examination aiming to determine relationships between infection and lesions. In 932 examinees we performed a 13C-urea breath test for H. pylori infection, and assessed degree of gastric atrophy by measuring pepsinogen I and II in serum. In 738 subjects we also performed upper gastrointestinal radiography with or without endoscopy.
Prevalence of H. pylori infection increased with age, and the ratio of serum pepsinogen I to II decreased with age. Prevalence of H. pylori infection did not differ significantly between subjects with and without radiographically or endoscopically evident lesions. Of H. pylori-positive subjects with peptic ulcer, 73.2% had no recurrence of ulcer despite absence of medical treatment.
Prolonged H. pylori infection was associated with atrophy of the gastric mucosa, but little relationship was evident between H. pylori infection and development or recurrence of peptic ulcer.
背景/目的：多项研究表明幽门螺杆菌感染与上消化道病变之间存在关联，但这种关系需要在未因相关症状就医的个体中进行评估。
我们在年度大规模健康检查期间对社区居民进行幽门螺杆菌感染和上消化道病变筛查，旨在确定感染与病变之间的关系。在932名受检者中，我们进行了13C尿素呼气试验以检测幽门螺杆菌感染，并通过测量血清中胃蛋白酶原I和II来评估胃萎缩程度。在738名受试者中，我们还进行了上消化道造影，部分受试者同时进行了内镜检查。
幽门螺杆菌感染率随年龄增长而升高，血清胃蛋白酶原I与II的比值随年龄增长而降低。有影像学或内镜可见病变的受试者与无病变受试者的幽门螺杆菌感染率无显著差异。在幽门螺杆菌阳性的消化性溃疡患者中，73.2%的患者在未接受治疗的情况下溃疡未复发。
幽门螺杆菌长期感染与胃黏膜萎缩有关，但幽门螺杆菌感染与消化性溃疡的发生或复发之间关系不明显。
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