Kato Seiichi, Nishino Yoshikazu, Ozawa Kyoko, Konno Mutsuko, Maisawa Shun-Ichi, Toyoda Shigeru, Tajiri Hitoshi, Ida Shinobu, Fujisawa Takuji, Iinuma Kazuie
Department of Pediatrics, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Japan.
J Gastroenterol. 2004 Aug;39(8):734-8. doi: 10.1007/s00535-004-1381-2.
Although Helicobacter pylori infection is typically acquired in childhood, the role of H. pylori infection in gastroduodenal diseases in childhood remains to be defined. The purpose of this study was to evaluate the prevalence of H. pylori infection in children with gastritis, duodenal ulcer, and gastric ulcer.
This was a retrospective analysis of 283 Japanese children (mean age, 11.5 years) with non-nodular gastritis ( n = 73), nodular gastritis ( n = 67), duodenal ulcer ( n = 100), and gastric ulcer ( n = 43). H. pylori status was based on biopsy tests. Clinical symptoms at the time of endoscopy were analyzed with regard to a possible association with the infection.
The prevalence of H. pylori in non-nodular gastritis, nodular gastritis, duodenal ulcer, and gastric ulcer was 28.8%, 98.5%, 83.0%, and 44.2%, respectively. H. pylori was significantly linked to duodenal ulcer and gastric ulcers in the age group of 10-16 years, but not in the age group of 9 years and under. In children with H. pylori infection, nodular gastritis was observed in 26.3% of gastric ulcer patients and in 74.7% of duodenal ulcer patients ( P < 0.001). H. pylori infection was significantly associated with the prevalence of anemia ( P < 0.05).
H. pylori is the most important causal factor for the development of duodenal ulcer in childhood. While H. pylori infection appears to be a risk factor in gastric ulcer, other causes are responsible for most cases. Nodular gastritis is the most common type of H. pylori gastritis in childhood. Chronic infection with H. pylori is associated with anemia.
尽管幽门螺杆菌感染通常在儿童期获得，但幽门螺杆菌感染在儿童胃十二指肠疾病中的作用仍有待确定。本研究的目的是评估胃炎、十二指肠溃疡和胃溃疡患儿中幽门螺杆菌感染的患病率。
这是一项对283名日本儿童（平均年龄11.5岁）进行的回顾性分析，这些儿童患有非结节性胃炎（n = 73）、结节性胃炎（n = 67）、十二指肠溃疡（n = 100）和胃溃疡（n = 43）。幽门螺杆菌状态基于活检检测。分析了内镜检查时的临床症状与感染的可能关联。
非结节性胃炎、结节性胃炎、十二指肠溃疡和胃溃疡中幽门螺杆菌的患病率分别为28.8%、98.5%、83.0%和44.2%。幽门螺杆菌与10 - 16岁年龄组的十二指肠溃疡和胃溃疡显著相关，但与9岁及以下年龄组无关。在幽门螺杆菌感染的儿童中，26.3%的胃溃疡患者和74.7%的十二指肠溃疡患者出现结节性胃炎（P < 0.001）。幽门螺杆菌感染与贫血患病率显著相关（P < 0.05）。
幽门螺杆菌是儿童十二指肠溃疡发生的最重要病因。虽然幽门螺杆菌感染似乎是胃溃疡的一个危险因素，但大多数病例是由其他原因引起的。结节性胃炎是儿童期幽门螺杆菌胃炎最常见的类型。幽门螺杆菌慢性感染与贫血有关。
