一种食用海藻提取物Viva-Natural对劳舍尔小鼠白血病的抗白血病活性与抗HIV药物叠氮胸苷、硫酸葡聚糖和聚硫酸戊聚糖的比较。

Antileukemic activity of Viva-Natural, a dietary seaweed extract, on Rauscher murine leukemia in comparison with anti-HIV agents, azidothymidine, dextran sulfate and pentosan polysulfate.

作者信息

Furusawa E, Furusawa S, Chou S C

机构信息

Department of Pharmacology, John A. Burns School of Medicine, University of Hawaii, Honolulu 96822.

出版信息

Cancer Lett. 1991 Mar;56(3):197-205. doi: 10.1016/0304-3835(91)90003-z.

DOI:10.1016/0304-3835(91)90003-z

PMID:1708693

Abstract

An antileukemic activity of partially purified polysaccharide of an edible seaweed. Viva-Natural, against Rauscher murine retrovirus-induced erythroleukemia has been demonstrated. This antileukemic effect is compared with standard anti-human immunodeficiency virus (HIV) agents, azidothymidine (AZT), dextran sulfate and pentosan polysulfate. Pretreatment with Viva-Natural, as an immunomodulator, on day 3 prior to the virus inoculation demonstrated definite prophylactic activity, while pretreatment with the other three anti-HIV agents showed no prophylactic activity. The replication of Rauscher virus in BALB/3T3 cell cultures accompanied by direct cytopathic effect (syncytia formation) was suppressed in the presence of Viva-Natural or the other anti-HIV agents in the culture medium. In spite of the antiviral potentials of the four agents in vitro, only Viva-Natural and AZT demonstrated therapeutic efficacy against Rauscher leukemia in mice.

摘要

一种可食用海藻的部分纯化多糖——Viva-Natural，对劳氏鼠逆转录病毒诱导的红白血病具有抗白血病活性。已证实该抗白血病作用与标准抗人免疫缺陷病毒（HIV）药物齐多夫定（AZT）、硫酸葡聚糖和聚硫酸戊聚糖进行了比较。在病毒接种前第3天，将Viva-Natural作为免疫调节剂进行预处理显示出明确的预防活性，而用其他三种抗HIV药物进行预处理则未显示出预防活性。在培养基中存在Viva-Natural或其他抗HIV药物的情况下，劳氏病毒在BALB/3T3细胞培养物中的复制以及直接细胞病变效应（多核巨细胞形成）受到抑制。尽管这四种药物在体外具有抗病毒潜力，但只有Viva-Natural和AZT对小鼠劳氏白血病显示出治疗效果。