Beliaeva N N
Gig Sanit. 2006 Sep-Oct(5):17-9.
The author proposes morphological criteria determining the risk of environment-induced diseases. The experimental studies analyzing 23 indices of the development of reparative regeneration in the liver of rats exposed to environmental factors have revealed that a significant change in the ratio of uni- and binuclear tetraploid hepatocytes is a criterion for the risk of hepatotoxic effect. Evaluation of the cytological status of nasal and oral mucosae, by using 21 indices has indicated that a significant reduction in the proportion of individuals with the normal cytological status is a criterion for the risk of environment-induced diseases.
作者提出了确定环境诱发疾病风险的形态学标准。对暴露于环境因素下的大鼠肝脏修复性再生发育的23项指标进行分析的实验研究表明，单核和双核四倍体肝细胞比例的显著变化是肝毒性作用风险的一个标准。通过使用21项指标对鼻和口腔黏膜的细胞学状态进行评估表明，细胞学状态正常的个体比例显著降低是环境诱发疾病风险的一个标准。
